Effect of protamine on alimentary lipemia.
نویسندگان
چکیده
The effect of protamine on the serum lipids during alimentary lipemia was investigated in normal male students and this effect was compared with that in atherosclerotic and in nonatherosclerotic men of the same age group. In the student group protamine produced a highly significant increase in the total fatty acid level, whereas in the 2 older groups no significant change occurred. These results were interpreted as demonstrating that circulating heparin exerts a physiologic effect on fat turnover in the young individual, an effect that is reduced with aging. It is suggested that the lowered fat tolerance known to occur with aging is the result of deficiency of circulating heparin.
منابع مشابه
Hemolysis and alimentary lipemia; effects of incubation, heparin, and protamine.
ITTLE ATTENTION has been paid to the observation of Longimui and Johnsontm that an alimentary lipemia may be responsible for increased fragility of erythrocytes. The possibility that the hemolysis may also occur in vivo is suggested by Loewy, et al.,2 who demonstrated that the output of bile pigment increased in dogs receiving high fat diets. More recently, Creditor3 has observed that hemolysis...
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THE effect of alimentary lipemia on coagulation has been a matter of controversy for most of the past decade. Reports have confirmed and denied an acceleration of whole blood coagulation.'-'0 A considerable amount of evidence is growing that purports to show lipemia as a factor in the pathogenesis of thrombotic disease, and perhaps even a factor in the genesis of atheroselerosis.1' These specul...
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THE effect of alimentary lipemia on coagulation has been a matter of controversy for most of the past decade. Reports have confirmed and denied an acceleration of whole blood coagulation.'-'0 A considerable amount of evidence is growing that purports to show lipemia as a factor in the pathogenesis of thrombotic disease, and perhaps even a factor in the genesis of atheroselerosis.1' These specul...
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متن کاملPlasma heparin levels. Correlation with serum cholesterol and low-density lipoproteins.
SINCE the original observations of the effect of heparin upon the clearing of alimentary lipemia,' much data have accumulated that indicate that heparin functions physiologically to facilitate the exit of alimentary triglycerides from the blood. The available evidence on this important question has recently been summarized.2 3 The nature of the heparin lipemia-clearing reaction involves the act...
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عنوان ژورنال:
- Circulation
دوره 16 1 شماره
صفحات -
تاریخ انتشار 1957